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MicroVue YKL-40
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Quidel manufactures a variety of YKL-40 products to support your research. EIA Kits, polyclonal and monoclonal antibodies as well as YKL-40 protien.
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Whats New with YKL-40

May 2011 Come see Quidel SPG at AAI

We will be profiling our research products including assays for bone health and the complement system....
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Oct 2010 Johansen et al. Clinical Chemistry

Increased plasma YKL-40 is associated with short-term survival in patients with cardiovascular disease and cancer. We tested the hypothesis that increased plasma YKL-40 is associated with total and disease-specific mortality in the general population. ...
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Apr 2009 Researches identify a role for YKL-40 in tumor angiogenesis

Shao et al presented their findings at the 100th AACR meeting in Denver, Co. The team identified an angiogenic role for YKL-40 in tumor growth and development. Ectopic expression of YKL-40 in MDA-MB-231 breast cancer cells and HCT-116 colon cancer cells led to an extensive angiogenic phenotype of xenografted tumors in SCID/Beige mice and these tumors were 4-8 fold larger than ...
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Feb 2009 Soel et al J Reproductive Immunology

Preeclampsia is a disease associated with the maternal inflammatory response. YKL-40 and interleukin-18 (IL-18) are inflammatory markers involved in inflammatory states and vascular processes. The aim of this study was to evaluate serum levels of YKL-40 and IL-18 in preeclampsia. Twenty-four patients with preeclampsia and 13 healthy pregnant women were included in this study. S...
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Feb 2009 Researchers link YKL-40 plasma and tissue expression to ovarian cancer

YKL-40 protein expression was found in cancer cells, tumor associated macrophages, neutrophils and mast cells. The tumor cell expression was higher in OC than in borderline tumors (p = 0.001), and associated with FIGO stage (p < 0.0001) and histological subtype (p = 0.0009). Positive YKL-40 expression (? 5% staining) was not associated with reduced survival. Plasma YKL-40 was a...
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YKL-40 Research and Development is a great resource for comprehensive information about YKL-40, a biomarker with potential application in early diagnosis of cancer. YKL-40 has shown promise in research studies as an early diagnostic and prognostic biomarker in ovarian, colorectal cancer and other cancers as well as rheumatoid arthritis and similar debilitating diseases.
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YKL-40 Background

The biological function of YKL-40 is unknown but it has been shown to be a potent growth factor and a potent migration factor for endothelial cells. While YKL-40 is not significantly expressed in normal tissues, several studies ...

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YKL-40 Publications

There is active research around YKL-40 as a biomarker in a variety of disease states. Recent studies have linked elevated YKL-40 levels to a variety of aggressive and invasive cancers, asthma and cirrhosis.

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